Jeffrey Amherst was already a hero when he and his men left Boston for Quebec in September of 1758.

Born in England in 1717, Amherst entered the British army at the not atypical age of 14. Although he was reasonably successful in his early career, it came as a surprise when in 1758 Prime Minister William Pitt promoted him to Major-General and put him in command of over 14,000 British troops. His mission was simple but daunting; he was charged with capturing the French stronghold of Louisburg on Cape Breton Island. Displacing the French from Louisburg would give the British a great strategic advantage on the American front.

Amherst's composure and perseverance served him well. After a two-month siege, the French surrendered on July 27, 1758. This would prove to be the turning point in the French and Indian War, or what Europeans more accurately called the Seven Years' War.

Having earned Pitt's, and the people's, confidence, Amherst was given command of all British troops in North America. Less than two months after the victory at Louisburg, he and his men left Boston for New France. They moved north from Albany towards Quebec, attacking French forts along the way. On July 27, 1759, exactly one year after his triumph at Louisburg, Amherst captured Fort Ticonderoga. Over the next year, he would play a vital role in the campaign to take control of Canada, which ended when the French surrendered Montreal on September 8, 1760.

Hostilities between the English and Native people did not cease with the end of the French and Indian War. During an uprising in 1763 known as Pontiac's Rebellion, Amherst was involved in what is considered the first documented attempt at biological warfare in North America. The general proposed to one of his senior officers that they infect the attacking Indians by giving them blankets infected with smallpox. "Could it not be contrived to send the small pox among the disaffected tribes of Indians? We must on this occasion use every stratagem in our power to reduce them," he wrote in June 1763. A month later, he reiterated: "You will do well to inoculate the Indians by means of blankets, as well as every other method that can serve to extirpate this execrable race."

Apparently, however, Amherst was not aware that the commander at Fort Pitt in Pennsylvania had already attempted this very tactic. He had given representatives of the besieging Delawares two blankets and a handkerchief that had been exposed to smallpox. While Indians in the area did indeed come down with smallpox, it is unclear how many of them (if any) contacted the disease as a result of the infected blankets. The dread disease was already present in the environs and may have been spread to the natives by their own warriors returning from attacks on infected white settlements. There is no doubt that British soldiers attempted to infect their Indian enemies with smallpox, but there is no evidence as to whether or not the attempt was successful.

With the defeat of Pontiac's Rebelion, the king bestowed titles and promotions on Amherst. "Lord Jeff" became Governor of Virginia and then in 1778 Commander in Chief of the British Army. The American colonists found their own ways to honor the military hero. Several New England towns took his name, most notably Amherst, Massachusetts. When people living in the eastern half of the overcrowded Connecticut Valley town of Hadley formed themselves into a new district in 1759, they called it Amherst, in recognition of Lord Jeff. The district was incorporated as a town in 1775.

The village was a center for education early in its history. In 1814 Amherst Academy, a three-story brick preparatory school, opened. It enrolled around 200 boys and girls a year from Amherst and surrounding towns, including, in the 1840s, the future poet Emily Dickinson, whose father was one of Amherst's leading citizens. 

In November of 1817, the Academy's trustees formed a committee to consider founding a college where young men with little or no money could study for the Christian ministry. What began as the Amherst Collegiate Institution in 1821 would become Amherst College only four years later. The first 25 graduates would receive degrees in 1825. For the next 150 years, all students at the elite college would be male. The first women were not admitted until 1975. For many years "Lord Jeff" served as an unofficial mascot for the college; however, in 2016 the trustees of Amherst College announced that Lord Jeffrey would no longer serve as its symbol, unofficial or otherwise.

Amherst has become a center of higher education in western Massachusetts. In 1863, the legislature chartered the Massachusetts Agricultural School, now the flagship campus of the University of Massachusetts. In 1972 a new college was founded within the town borders — Hampshire College. Amherst's three colleges are part of a five-college consortium that also includes Smith College in Northampton and Mt. Holyoke College in South Hadley. Students at the five colleges enjoy the benefits of cross-registration and library access.